Platelet-Derived Growth Factor–Producing CD4 ⁺ Foxp3 ⁺ Regulatory T Lymphocytes Promote Lung Fibrosis

Abstract

Our study indicates that T reg cells contribute to lung fibrosis by stimulating fibroblasts through the secretion of PDGF-B in noninflammatory conditions and regulate detrimental T eff cell activities during inflammation-related fibrosis.