Antispasmodic Activity of SJ-200 (Himcospaz): An Herbal Preparation

Abstract

SJ-200 (Himcospaz), an herbal preparation, was investigated for antispasmodic activity on gastrointestinal smooth muscles of guinea pig, rats, rabbits and mice. SJ-200 dosedependently inhibited acetylcholine, histamine and barium chloride-induced contraction of guinea pig ileum. It inhibited spontaneous contraction of rabbit and rat colon. Oxytocin-induced contraction of rat uterus was also inhibited. Oral administration of SJ-200 dose-dependently reduced gastric emptying in rats and intestinal transit in mice. All these findings suggest the non-specific antispasmodic activity of SJ-200 in experimental models.