Phosphine‐Free, Palladium‐Catalyzed Arylation of Heterocycles through CH Bond Activation with Pivalic Acid as a Cocatalyst

Abstract

Ligand-free C-arylation: A general palladium-catalyzed C-arylation of N-heterocycles with aryl bromides has been performed without the presence of phosphines, the aid of CuI, or other metal additives by using pivalic acid as a cocatalyst (see scheme). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.