Independent Modulation of Engagement and Connectivity of the Facial Network During Affect Processing by<i>CACNA1C</i>and<i>ANK3</i>Risk Genes for Bipolar Disorder

Abstract

Our data demonstrate that the effect of CACNA1C rs1006737 and ANK3 rs10994336 (or genetic variants in linkage disequilibrium) on the brain converges on the neural circuitry involved in affect processing and provides a mechanism linking BD to genome-wide genetic risk variants.