Stoffwechselprodukte von Mikroorganismen. 98. Mitteilung. Phosphinothricin und Phosphinothricyl‐Alanyl‐Alanin

Abstract

Abstract From cultures of Streptomyces viridochromogenes a new antibiotic, phosphinothricylalanyl‐alanine, has been isolated. The new amino acid phosphinothricin is 2‐amino‐4‐methyl‐phosphino‐butyric acid, its structure is confirmed by synthesis. The tripeptide is highly active against Gram ‐positive and Gram ‐negative bacteria and against the fungus Botrytis cinerea . Phosphinothricin is an active glutamine synthetase inhibitor.