Inhibition of Neointima Hyperplasia of Mouse Vein Grafts by Locally Applied Suramin

Abstract

Suramin inhibited SMC migration and proliferation in vivo and in vitro by blocking PDGF-initiated PDGF receptor and MAPK-AP-1 signaling. These findings indicate that locally applied suramin is effective in a mouse model of venous bypass graft arteriosclerosis.