British Journal of Clinical Pharmacology · 1991 · 14 citations · 27 references
MedicinePharmacokineticsPharmacologyCardiovascular PharmacotherapyClinical PharmacologyGeneral PharmacologyAcute Coronary SyndromesCardiac MedicationsCardiac PharmacotherapyCardiovascular PharmacologyIschemic Heart DiseaseBioassay ValidationIschemic Heart Disease PharmacologyMyocardial Infarction PharmacotherapyPharmacokinetic Study DesignPharmacokinetics Of Cardiovascular DrugsPharmacokinetics Of Thrombolytic AgentsPost-myocardial Infarction PharmacotherapyResidence Time
1. The pharmacokinetics of streptokinase (SK) and anistreplase in conventional dosage regimens of 1.5 x 10(6) i.u. of SK infused over 60 min and 30 units of anistreplase over 5 min were studied in 24 consecutive patients presenting with acute myocardial infarction, using a functional bioassay to assess concentrations. 2. The two agents were found to have similar volumes of distribution (5.68 and 5.90 l), but SK was cleared significantly more rapidly than anistreplase, resulting in a shorter terminal phase half-life (0.61 vs 1.16 h) and a shorter mean residence time (0.76 vs 1.55 h).
27