Retargeting of adenoviral vector using basic fibroblast growth factor ligand for malignant glioma gene therapy

Abstract

Altogether, the results demonstrated that AdV-mediated gene transfer using the FGF2/FGFR system is effective in gliomas with low or deficient levels of CAR and suggested that FGF2-retargeting of AdV may be a promising approach in glioma gene therapy.