RGD-labeled USPIO Inhibits Adhesion and Endocytotic Activity of α_vβ₃-Integrin–expressing Glioma Cells and Only Accumulates in the Vascular Tumor Compartment

Abstract

In glioma cells with unstable intercellular contacts, inhibition of alpha(v)beta(3) integrins by antibodies and RGD and RGD-USPIO disintegrated intercellular contacts and reduced endocytotic activity, illustrating the risk of inducing biologic effects by using molecular MR probes.