HIV-1 Nef Is Associated with Complex Pulmonary Vascular Lesions in SHIV- <i>nef</i> –infected Macaques

Abstract

The discovery of complex vascular lesions in SHIV-nef- but not SIV-infected animals, and the presence of Nef in the vascular cells of patients with HRPH, suggest that Nef plays a key role in the development of severe pulmonary arterial disease.