A Hemin/G‐Quadruplex Acts as an NADH Oxidase and NADH Peroxidase Mimicking DNAzyme

Abstract

Enzyme impressionist: A DNAzyme consisting of hemin combined with a G-quadruplex was shown to mimic the activity of NADH oxidase under aerobic conditions and of NADH peroxidase under anaerobic conditions. Along with these new biocatalytic activities, the hemin/G-quadruplex complex is also capable of regenerating the biologically important NAD+ cofactor in both cycles (see picture).