Demonstration of Thrombophlebitis and Endothelial Damage by Scintiscanning

Abstract

Several particulate radiotracers were studied with respect to their behavior in the vicinity of clots. Experiments were performed in vitro, microscopically and quantitatively, and in vivo on artificially created lesions. Of the particles studied, macroaggregates of albumin and aggregates of stannous hydroxide showed the best accumulation on clots and venous lesions. It was concluded that there is definite demonstrable clot affinity for some particles and not for others. The mechanism remains to be elucidated. Clinical usefulness is to be evaluated.