Heteromerization of<scp>GPR</scp>55 and cannabinoid<scp>CB</scp>₂receptors modulates signalling

Abstract

Heteromers, unique signalling units, form in HEK293 cells expressing GPR55 and CB2 receptors. The signalling by agonists of either receptor was governed (i) by the presence or absence of the partner receptors (with the consequent formation of heteromers) and (ii) by the activation state of the partner receptor.