An Asymmetric Catalytic Darzens Reaction between Diazoacetamides and Aldehydes Generates <i>cis</i>‐Glycidic Amides with High Enantiomeric Purity

Abstract

Titanium strength: The title reaction was catalyzed by a chiral titanium complex formed in situ from commercially available Ti(OiPr)4 and (R)-binol, and gave cis-glycidic amides with excellent enantiomeric purity (see scheme). This new method has been applied to the preparation of chiral building blocks used for the synthesis of the side chain of taxol and (−)-bestatin.