Antibody Responses to Hepatitis A Virus Vaccine in HIV‐Infected Children with Evidence of Immunologic Reconstitution while Receiving Highly Active Antiretroviral Therapy

Abstract

HIV-infected children with CD4+ T cell percentages > or = 20% responded better to the HAV vaccine if they had undetectable HIV RNA. The standard 2-dose immunization regimen generated low antibody titers with limited persistence. A third vaccine dose was safe and increased the antibody titers, suggesting that an increase in immunizations may be warranted in this population.