Integrin α_vβ₃-Targeted Radiotracer ^99mTc-3P-RGD₂ Useful for Noninvasive Monitoring of Breast Tumor Response to Antiangiogenic Linifanib Therapy but not Anti-Integrin α_vβ₃ RGD₂ Therapy

Abstract

(99m)Tc-3P-RGD₂ is an excellent radiotracer for monitoring integrin α(v)β₃ expression during and after linifanib therapy. (99m)Tc-3P-RGD₂ SPECT/CT is an useful molecular imaging tool for patient selection before antiangiogenic and anti-α(v)β₃ therapy; but it would be difficult to use (99m)Tc-3P-RGD₂ for accurate and noninvasive monitoring of early tumor response to anti-α(v)β₃ therapy.