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THE EXPERIMENTAL (IN VITRO) AND CLINICAL (IN VIVO) IMMUNOSUPPRESSIVE EFFECTS OF A RAT IgG2b ANTI-HUMAN CD2 mAb, LO-CD2a/BTI-3221

DOIFull Paper Access

20

Citations

45

References

2000

Year

Yannick Nizet, Aziz Alami Chentoufi, Bernardo De La Parra, Philippe Lewalle, Rédouane Rouas, Anne Cornet, Tatianna Besse, Michel Mourad, Jacques Malaise, Jean‐Paul Squifflet,
Transplantation

Abstract

The correlation between the in vitro and in vivo data suggests that T-cell depletion, especially of activated cells, and inhibition of cell activation after CD2 down-modulation are the main mechanisms of action of the LO-CD2a/BTI-322 mAb.

References

YearCitations

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