Polyadenylic-polyuridylic acid, an adjunct to surgery in the treatment of spontaneous mammary tumors in C3H-He mice and transplantable melanoma in the hamster.

Abstract

In mice bearing spontaneous mammary adenocarcinoma, treatment with double-stranded polynucleotide complex poly A-poly U (a nontoxic stimulator of cell-mediated immunity) was a potent adjunct to surgery by reducing the rate of tumor growth and increasing significantly the mean survival time. In hamsters bearing a highly metastasizing transplantable melanoma, poly A-poly U reduced the appearance of early metastases by 50% as compared with untreated animals or animals treated by surgery alone.