Satellite Glial Cell P2Y₁₂Receptor in the Trigeminal Ganglion is Involved in Lingual Neuropathic Pain Mechanisms in Rats

Abstract

The present findings provide the first evidence that the activation of P2Y12R in SGCs of TG following lingual nerve injury is involved in the enhancement of TG neuron activity and nocifensive reflex behavior, resulting in neuropathic pain in the tongue.