Pulsed Ultrasound Enhances the Killing of <i>Escherichia coli</i> Biofilms by Aminoglycoside Antibiotics In Vivo

Abstract

Escherichia coli biofilms on two polyethylene disks were implanted subcutaneously into rabbits receiving systemic gentamicin. Ultrasound was applied for 24 h to one disk. Both disks were removed, and viable bacteria were counted. Pulsed ultrasound significantly reduced bacterial viability below that of nontreated biofilms without damage to the skin.