Radiosurgery of the Rat Hippocampus: Magnetic Resonance Imaging, Neurophysiological, Histological, and Behavioral Studies

Abstract

This study expands our understanding of the effects of radiosurgery on the mammalian brain. Three months after PBR, the irradiated rat hippocampus demonstrates necrosis at 90 CGE, but not at 60 CGE, with associated abnormalities in magnetic resonance imaging, physiology, and memory testing. HSP-72 was up-regulated at nonnecrotic doses.