Observation of a Transient Intermediate in Soai’s Asymmetric Autocatalysis: Insights from ¹H NMR Turnover in Real Time

Abstract

Caught in the act: 1H NMR spectroscopy was used to monitor the loss of reactant and formation of product during the induction and burst phases of Soai's autocatalysis reaction. A transient intermediate was observed at 0 °C and identified as an alkoxyacetal formed from one aldehyde and two alkoxide moieties (see picture). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.