Diastereo‐ and Enantioselective Catalytic Tandem Michael Addition/Mannich Reaction: Access to Chiral Isoindolinones and Azetidines with Multiple Stereocenters

Abstract

Michael and Mannich cooperate: A rapid and reliable approach to highly functionalized chiral isoindolindone and azetidine derivatives, possessing multiple contiguous stereogenic centers, has been achieved (see scheme).