Synthesis of 4‐Deoxyaklanonic acid and Its Microbial Conversion into Anthracyclinones

Abstract

With a mutant strain of Streptomyces galilaeus, a cinerubin producer, the unnatural 4-deoxyaklanoic acid 1 can be converted into the enantiomerically pure 4-deoxyaklavinones 2 and 3. Through this combination of chemical synthesis and multistep biotransformation, the preparation of glycosidic anthracyclines should be possible, for which improved antitumor properties are expected.