Copper‐Catalyzed Cascade Reactions of Substituted 4‐Iodopyrazolecarbaldehydes with 1,2‐Phenylenediamines and 2‐Aminophenols

Abstract

Abstract A new approach for the synthesis of novel annulated‐pyrazoles is presented. This protocol includes an intermolecular condensation followed by a copper‐mediated intramolecular CN or CO coupling reaction. The method is applied to a range of substituted 4‐iodopyrazolecarbaldehydes which react with 1,2‐phenylenediamines or 2‐aminophenols to yield substituted 2,4‐ or 1,4‐dihydrobenzo[ b ]pyrazolo[4,3‐ e ][1,4]diazepines or substituted‐2 H‐ or 1 H ‐benzo[ b ]pyrazolo[3,4‐ f ][1,4]oxazepines, respectively.