Phosphodiesterase 5 Inhibition with Sildenafil Reverses Exercise Oscillatory Breathing in Chronic Heart Failure: A Long-Term Cardiopulmonary Exercise Testing Placebo-Controlled Study

Abstract

PDE5 inhibition in HF patients with EOB offers the dual advantage of improving functional capacity and modulating the EOB pattern. PAP and PVR reduction seem to underlie the correction of the breathing disorder. Whether reversal of this unfavourable prognostic signal can affect survival remains unconfirmed at the moment.