A NEW ANTIBIOTIC, MACROMOMYCIN, EXHIBITING ANTITUMOR AND ANTIMICROBIAL ACTIVITY

Abstract

A macromolecular peptide was isolated from a culture filtrate of Streptomyces macromomyceticus n. sp. which is described in this paper. Macromomycin was isolated as a white powder by precipitation with ammonium sulfate, followed by dialysis, Dowex 1X2 column chromatography and Sephadex chromatography. It is a peptide with Sw20 value of 1.27 and a molecular weight of about 15, 000. It inhibits sarcoma 180 and mouse leukemia L-1210. It inhibits S. aureus, M. flavus, S. lutea, B. subtilis, and B. anthracis.