Clinical and Histological Healing of Surgical Wounds Treated With Mitomycin C

Abstract

Topical mitomycin C delays the healing of surgical wounds in rats up to the fourth week following treatment, but the degree of fibrosis is comparable in both treated and untreated wounds after 12 weeks. In otolaryngology this characteristic of the drug may be useful in the treatment of external ear canal stenosis, choanal atresias, nasal cicatricial stenosis, laryngeal stenosis, and keloids.