Ribosomal Synthesis of Tricyclic Depsipeptides in Bloom‐Forming Cyanobacteria

Abstract

Decoding biosynthesis: Cage-like depsipeptides have been investigated by a combination of genetic and chemical analyses. Heterologous expression and MALDI-PSD studies reveal that the cyanobacterial protease inhibitors microviridin B and J are synthesized from ribosomally produced prepeptides that are transformed into tricyclic depsipeptides by ATP grasp ligases and processed by a transporter peptidase. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z802730_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.