Interaction of fibrinogen with murine melanoma cells: covalent association with cell membranes and protection against recognition by lymphokine-activated killer cells.

Abstract

B16/F10 melanoma cells, in a medium containing fibrinogen, form a coating of fibrin(ogen) on their surfaces. This coating is cross-linked in a manner characteristic of catalysis by cellular transglutaminase. The fibrin(ogen) coating on the surface of these tumor cells provides protection against the lytic effect of autologous lymphokine-activated killer cells.