Healing of the bones in juvenile Paget's disease treated by human calcitonin

Abstract

A 6-year-old boy with juvenile Paget's disease and recurrent fractures has been treated by daily intramuscular injections of 1 mg of synthetic human calcitonin for 16 months. Regression of the bony abnormalities was apparent within seven months of the start of treatment. Levels of serum alkaline phosphatase and urine hydroxyproline fell during the first four months, but have remained high ever since. We suggest that these continuing high levels reflect in part the healing of the diseased bones.