Dialyzable Carbosilane Dendrimers as Soluble Supports for the Functionalization of Pyridine Fragments via Palladium-Catalyzed Coupling Reactions

Abstract

[reaction: see text] The use of carbosilane (CS) dendrimers as soluble supports in liquid phase organic synthesis (LPOS) is described. Control of the three key steps is perfectly achieved by covalently binding a pyridine fragment to the soluble support, modifying it via coupling reactions, and releasing it at the end. Nanofiltration (dialysis) allows facile purification of the supported molecules after each step.