Shift toward T helper 1 cytokines by type II collagen-reactive T cells in patients with rheumatoid arthritis

Abstract

CII-reactive T cells are more abundant in SFMC than in PBMC and are strongly associated with a shift toward Thl cytokine in the inflamed joints of RA patients. Our results suggest that a skewing toward type 1 cytokines by CII-reactive T cells may play an important role in the chronic inflammatory process of RA.