Synthesis of Rigid Analogues of Flavone by Intramolecular Heck Reaction

Abstract

Abstract A novel concise method to synthesize rigid analogues of flavone by an intramolecular Heck reaction with wide substrate scope was developed. The key intermediates 3‐(2‐bromobenzyl)‐4 H ‐chromen‐4‐ones were prepared easily in two steps. Most compounds were obtained with moderate to good yields (34–90 % yield, 19 examples).