Concise One‐Pot Tandem Synthesis of Indoles and Isoquinolines from Amides

Abstract

Heterocyclic hot pot: Platinum(II)-catalyzed syntheses of indoles and isoquinolines from isocyanates, which are derived from a Hofmann-type rearrangement of amides using a hypervalent iodine reagent, are described. C2-symmetric macrocyclic bis(indole)s can also be synthesized from transannulation of C2-symmetric macrocyclic bis(alkyne carbamate) intermediates.