Genetic Variants in<i>CYP2R1</i>,<i>CYP24A1</i>, and<i>VDR</i>Modify the Efficacy of Vitamin D₃Supplementation for Increasing Serum 25-Hydroxyvitamin D Levels in a Randomized Controlled Trial

Abstract

The increase in [25(OH)D] attributable to vitamin D3 supplementation may vary according to common genetic differences in vitamin D 25-hydroxylase (CYP2R1), 24-hydroxylase (CYP24A1), and the vitamin D receptor (VDR) genes. These findings have implications for achieving optimal vitamin D status and potentially for vitamin D-related health outcomes.