Ultrasonic Assisted Synthesis of Naphthalene Substituted Schiff Base Derivatives and Their Antioxidant Activity Studies

Abstract

Abstract New Schiff base derivatives, 2,2′‐[naphthalene‐2,7‐diylbis(oxy)]bis[N′‐substituted acetohydrazide] ( 4a‐m ) were synthesized by the acid catalyzed condensation of aryl/hetero aromatic aldehydes with 2,2′‐ [naphthalene‐2,7‐diylbis(oxy)]diacetohydrazide ( 3 ) under reflux temperature and ultrasonic irradiation. These Schiff base derivatives were confirmed through spectral characterization using IR, 1 H NMR, 13 C NMR and mass spectra. All the synthesized compounds were screened for their antioxidant activity using DPPH free radical scavenging method.