ROLE OF CLASSICAL (RT1.A) AND NONCLASSICAL(RT1.C) MHC CLASS I REGIONS IN NATURAL KILLER CELL-MEDIATED BONE MARROW ALLOGRAFT REJECTION IN RATS1

Abstract

This investigation shows that rat effector NK cells are radioresistant, independent of the thymus, and capable of recognizing and rejecting MHC mismatched transplanted BMC on the basis of mismatches in both classical and nonclassical class I regions in vivo. The studies underline the importance also of NK cells in determining BMC allograft survival.