Novel Role of Reactive Oxygen Species–Activated <i>trp</i> Melastatin Channel-2 in Mediating Angiogenesis and Postischemic Neovascularization

Abstract

VEGF-induced angiogenesis and postischemic neovascularization in mice required reactive oxygen species generation in endothelial cells and resultant TRPM2 activation. Thus, our findings provide novel insight into the role of TRPM2 in mechanism of angiogenesis and ischemic neovascularization.