Highly Enantioselective Pd‐Catalyzed Allylic Alkylations of Acyclic Ketones

Abstract

Pocket the difference: Highly enantioselective allylic alkylation of simple acyclic ketones is carried out by using a Pd catalyst with a “chiral pocket” ligand 1 (see scheme). The addition of a Lewis acid such as AgBr and the selection of one enolate form over another dramatically affect the enantioselectivity of the reaction. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z502020_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.