A High‐Performance Ytterbium‐Based Nanoparticulate Contrast Agent for In Vivo X‐Ray Computed Tomography Imaging

Abstract

Enlightening particles: A contrast agent for in vivo X-ray computed tomography (CT) imaging is composed of an Yb-based nanoparticle (NP) that is stabilized with oleic acid and modified with the biocompatible polymer DSPE-PEG 2000 (see picture). The contrast agent exhibits long circulation time in vivo and low toxicity and is also much more effective than a clinical iodinated agent.