BODIPY‐Based Fluorescent Redox Potential Sensors that Utilize Reversible Redox Properties of Flavin

Abstract

Back and forth. Redox potential sensors that consist of a flavin unit, a bora-3a,4a-diaza-s-indacene (BODIPY) moiety, and a L-proline linker are presented. While reduced forms of these fluorescent sensors are almost nonfluorescent, their oxidized forms exhibit bright emissions under control of the redox status of the flavin unit. It is also shown that these changes are reversible in aqueous solutions and living cells, as illustrated in the figure. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2268/2008/z700718_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.