Total Synthesis and Biological Evaluation of Monorhizopodin and 16‐<i>epi</i>‐Monorhizopodin

Abstract

Convergence and a biological dichotomy! Monorhizopodin (see structure) and its C16 epimer have been synthesized through a highly convergent strategy. Unlike the antitumor agent rhizopodin which is their naturally occurring dimer, monorhizopodin and its epimer exhibit potent inhibition of actin polymerization but no significant cytotoxicity.