HMG-CoA reductase inhibitors up-regulate anti-aging klotho mRNA via RhoA inactivation in IMCD3 cells - Concepedia

Concepedia

Publication | Closed Access

HMG-CoA reductase inhibitors up-regulate anti-aging klotho mRNA via RhoA inactivation in IMCD3 cells

66

Citations

29

References

2004

Year

Hiromichi Narumiya, S. Sasaki, Noriko Kuwahara, H. Irie, Tetsuro Kusaba, H. Kameyama, Keiichi Tamagaki, Tsuguru Hatta, Kazuya Takeda, Hiromi Matsubara

Cardiovascular Research

Abstract

Statins inactivate the RhoA pathway, resulting in over-expression of klotho mRNA, which may contribute to the novel pleiotropic effects of statins towards vascular protection.

References

	Year	Citations

Page 1