Recombinant Sendai Virus Vector Induces Complete Remission of Established Brain Tumors through Efficient <i>Interleukin-2</i> Gene Transfer in Vaccinated Rats

Abstract

The present results show that the recombinant nontransmissible SeV vector provides efficient in vivo gene transfer that induces significant regression of the established brain tumors and suggest that it will be a safe and useful viral vector for the clinical practice of glioma gene therapy.