Maternal deprivation alters epithelial secretory cell lineages in rat duodenum: role of CRF-related peptides

Abstract

The activation of CRFR(1) and CRFR(2) induced by MD markedly altered the quantitative distribution of secretory cells of the intestinal epithelium. These alterations, in particular the depletion of Paneth and goblet cells, may create conditions leading to the development of an epithelial barrier defect.