Synthesis and Application of New, Optically Active Compounds as Catalysts and Ligands in Enantioselective Reactions

Abstract

New methods for efficient preparation of optically active compounds developed recently are reported. Combination of selective organometallic, organocatalytic, phase transfer catalytic and catalytic hydrogenation reactions provided numerousnew optically active members of the families of atropisomeric 1-phenylpyrrole derivatives, 4-aminobutan-1-ol and 3,4-disubstituted pyrrolidine derivatives and optically active α- and β-aminophosphonic acids. The products can be used as valuable new chiral ligands or organocatalysts and can serve as building blocks of practically important biologically active compounds.