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Synthesis of δ-lactone, oxetane and azetidinone analogs from the naturally occurring β-lactone L-659,699. The preparation of a novel HMG CoA synthase inhibitor.

Medicinal ChemistryNatural Product SynthesisBiochemistryMedicineNatural SciencesDrug DevelopmentAzetidinone AnalogsPharmacologyPharmaceutical ChemistrySynthetic ChemistryDrug Discoveryβ-Lactone L-659,699