HDAC Dependent Transcriptional Repression of <i>Bmp-7</i> Potentiates TGF-β Mediated Renal Fibrosis in Obstructive Uropathy

Abstract

These findings show that histone deacetylase dependent repression of Bmp-7 transcription is a critical event during the pathogenesis of renal injury in obstructive uropathy. Accordingly, treatment with histone deacetylase inhibitors represents a potentially effective strategy to restore BMP-7 expression and its renal protective functions during treatment of obstructive uropathy.