Preliminary Study of Injury From Heating Systemically Delivered, Nontargeted Dextran–Superparamagnetic Iron Oxide Nanoparticles in Mice

Abstract

Magnetic nanoparticles producing only modest heat output can cause damage, and even death, when sequestered in sufficient concentrations. Dextran-superparamagnetic iron oxide nanoparticles are deposited in the liver and spleen, making these the sites of potential toxicity. Original submitted 16 August 2011; Revised submitted 21 March 2012; Published online 26 July 2012.